Can I auto reply two group in same time?

for example

group a
abc.txt

group b
cda.txt

and can I set different auto reply delay for each group?

for example

group a
reply every 30 min

group b

reply every 1 hour

thank

Yes, you can reply at the same time.

And no, you can't set different flood delay.

can I use the normal reply while auto reply is running?

Yes, you can.

how about schedule reply?

You can everything.